TORONTO -- Blue Jays reliever Daniel Hudson was pitching in the top of the eighth inning and had a runner on first with one out, when Padres first baseman Eric Hosmer hit a 97 mph fastball up the middle.

Hudson made a great play to get the ball, which set up a double-play opportunity. However, Hudson missed shortstop Freddy Galvis on the throw, which allowed Hosmer to reach safely and give the Padres runners at the corners.

On the very next at-bat, Hunter Renfroe took Hudson deep for a tiebreaking three-run homer, which provided the final margin in the Blue Jays' 6-3 loss at Rogers Centre on Friday night.

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¡°We had a chance to turn that double play and we didn¡¯t do it, and that¡¯s why we lost that game, actually,¡± manager Charlie Montoyo said. ¡°I know we only had three hits, but we battled back and we were in the game. He made a big pitch and got the ground ball, but he just couldn¡¯t finish and threw the ball away.¡±

Although he wasn¡¯t in line for a decision by the time he came out, the three-run eighth inning put a damper on a solid pitching performance from Toronto starting pitcher Trent Thornton, who found himself ingrained in a pitching duel.

The rookie pitcher delivered a quality start and a career-high 10 strikeouts over six innings of work. Thornton was solid going up against Padres starter Joey Lucchesi, who was perfect through 4 1/3 innings and struck out 11 in 6 2/3 innings overall.

¡°I felt pretty good. My stuff was the best it has felt all year. I made two mistake pitches,¡± Thornton said of his performance. ¡°The defense played pretty great and we swung the bats when we needed to for the most part. We just came out on the wrong side tonight.¡±

Thornton went six innings while allowing three runs on four hits while walking three batters. He threw 112 pitches, the most of any Blue Jay in a game this season, with 62 of them for strikes.

Toronto trailed 3-0 in the fifth inning when it started a comeback bid.

Freddy Galvis hit a two-run homer off the top of the left-field fence, which cut the Padres¡¯ lead to 3-2. Lourdes Gurriel Jr., called up on Friday from Triple-A Buffalo, made it back-to-back homers to tie the game, 3-3.

¡°It was good to see Gurriel go opposite field. That¡¯s a good sign,¡± Montoyo said. ¡°And the balls he fielded, one of them wasn¡¯t easy. That was also a good sign.¡±

Toronto finished the game with just three hits, as run support continues to be an issue. The club came into Friday¡¯s game with an MLB-low .201 batting average at home.

Cavan Biggio went 0-for-3 in his Major League debut. Along with Vladimir Guerrero Jr., they became the first sons of Hall of Famers to play on the same team.